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Scientist, Biologics Engineering, Oncology R&D

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Gaithersburg, MD

Employer:  AstraZeneca
Job Type:  Full Time

Description

We are seeking a skilled Scientist to enhance our High Throughput Production & Screening (HTPS) capabilities of biologics. The ideal candidate will play a critical role in a dynamic group responsible for high throughput expression & purification of antibody therapeutics on a microgram-to-milligram scale and be an advocate for utilizing various automation platforms. The selected individual will be a well-organized and a highly productive scientist that can design and execute experiments efficiently, as well as analyze, interpret, and present data to multidisciplinary project teams.

SITE DESCRIPTION

Our Gaithersburg, Maryland facility creates life-changing medicines for people around the world. This campus employs more than 3,500 experts in our field. This modern and vibrant scientific campus is the home of R&D and Oncology in the US. Here, we play host to some of the most cutting-edge technology and lab spaces, all designed to inspire collaboration and cross-functional science. We believe employees benefit from being challenged and inspired at work. We are dedicated to creating a culture of inclusion and collaboration. The Gaithersburg site offers a variety of amenities to help boost productivity and help keep our employees stay happy and healthy. This includes a fitness center, employee healthcare clinic, electric vehicle charging stations, dry cleaning, full-service cafeteria and copy center. This is where you'll find newly-designed, activity-based work spaces to suit a variety of working styles while increasing collaboration between teams.

BUSINESS AREA

Biologics Engineering (BE) is large global organization with sites located in Gaithersburg MD, Waltham MA, and Cambridge, UK responsible for the discovery and optimization of next generation biologics to create biological drug candidates for all key therapeutic areas such as oncology, respiratory and inflammation, cardiovascular, renal and metabolic diseases.

What you'll do
  • Collaborate and work with a diverse group of scientists across all therapeutic areas to ensure timely progress in research projects.
  • Execute high-throughput production and purification of protein therapeutics from bacterial or mammalian expression systems using process automation and liquid handling robotics.
  • Biochemical, biophysical and functional profiling of antibodies and recombinant antibody fragments.
  • Cell Culture
  • Cloning both Gibson Assembly and Golden Gate desired

Essential for the role
  • MS with 1+ years of experience OR BS with 5+ years of experience
  • Experience in molecular and cell biology techniques, including; cloning, transfection and transduction methods.
  • Experience in expression, purification and biochemical/ biophysical characterization of various antibody formats.
  • Experience in optimizing/troubleshooting automation techniques (e.g. Hamilton liquid handler) with a problem-solving mindset.
  • Experience in sample tracking and laboratory logistics software.
  • Experience in tissue culture techniques and functional cell-based assay development.
  • Must be able to work in a team environment.

Desirable for the role
  • Experience in antibody discovery using several cloning and purification technologies.
  • Analytical experience with UPLC, HPLC, Mass Spec.
  • Eagerness to learn.

Why AstraZeneca?

At AstraZeneca when we see an opportunity for change, we seize it and make it happen, because any opportunity no matter how small, can be the start of something big.

So, what's next!
  • Are you already imagining yourself joining our team? Good, because we can't wait to hear from you.

Where can I find out more?

Our Social Media, Follow AstraZeneca on LinkedIn: https://www.linkedin.com/company/1603/

Inclusion & Diversity: https://careers.astrazeneca.com/inclusion-diversity

Career Site: https://careers.astrazeneca.com/

AstraZeneca embraces diversity and equality of opportunity. We are committed to building an inclusive and diverse team representing all backgrounds, with as wide a range of perspectives as possible, and harnessing industry-leading skills. We believe that the more inclusive we are, the better our work will be. We welcome and consider applications to join our team from all qualified candidates, regardless of their characteristics. We comply with all applicable laws and regulations on non-discrimination in employment (and recruitment), as well as work authorization and employment eligibility verification requirements.
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